Evidence is reviewed here that inositol (1, 4, 5) trisphosphate (Ins P3) is a key signal in translating the electrophysiological event in muscle stimulation into the molecular‐mechanical events of contraction. Not least, these findings raise questions about the suitability of the term ‘second messenger’.

Rapid developments in Artificial Intelligence are leading to an increasing human reliance on machine decision making. Even in collaborative efforts with Decision Support Systems (DSSs), where a human expert is expected to make the final decisions, it can be hard to keep the expert actively involved throughout the decision process. DSSs suggest their own solutions and thus invite passive decision making. To keep humans actively ‘on’ the decision-making loop and counter overreliance on machines, we propose a ‘reflection machine’ (RM). This (...) system asks users questions about their decision strategy and thereby prompts them to evaluate their own decisions critically. We discuss what forms RMs can take and present a proof-of-concept implementation of a RM that can produce feedback on users’ decisions in the medical and law domains. We show that the prototype requires very little domain knowledge to create reasonably intelligent critiquing questions. With this prototype, we demonstrate the technical feasibility to develop RMs and hope to pave the way for future research into their effectiveness and value. (shrink)

This paper will survey and assess the ways in which moral thinkers in the early modern tradition of casuistry considered a range of cases of conscience (casus conscientiae) relating to lying, deception, and witholding the truth. Arguing that the position of the casuists has been unjustly maligned — not least by Pascal's brillant yet partizan Les Proviniciales — casuistical theories of lying and simulation will be placed in a broad intellectual context which will examine attihules to mendacity among early modern (...) medical writers, political theorists, anbl philosophers. Contrasting casuistical theoriessuch as equivocation and mental reservation with the approach to lying of other early modern writers, the lecture will advancfcahe view that the casuists promulgated a conceptual outlook on the differences betweefc lying and deception which is of inherent interest, and which helps to clarify some of the salient issues that attend a philosophical account of lying. (shrink)

We present our personal view on W.J. Blok's contribution to modal logic.

This chapter contains section titled: I Aristotle and Early Modern Philosophy II Medieval Thought in Early Modern Scholasticism III The Philosophical Textbook IV Conclusions.

This collection of new essays locates Boethius' Consolatio Philosophiae in the medieval context of Latin learning and vernacular translations. The first part is devoted to the Latin commentary tradition, while the other parts explore the vernacular traditions.